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Chronic granulomatous disease Chronic granulomatous disease (CGD) is a rare genetic disorder that affects the activity of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex of phagocytic cells ( phox and p22 phox ( phox , p47 phox , and p40 phox ( CYBB gene encoding gp91 phox accounts for 65% of the diagnosed CGD cases in Europe and North America ( phox , p47 phox , and p67 phox account for 25%, 5%, and 5% of the cases, respectively ( Table 1 )