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Metabolic stress induces a prioritization of metabolites to cell survival rather than myelin maintenance, resulting in myelin loss and white matter damage, which can be observed in PLWH

While nothing can be done to address the genetic vulnerability, you can lessen the impact of the triggers and treat the underlying causes of the autoimmune disorder

In terms of the BIC index, the BIC value suggests that the difference between the two models is also small (i.e., 6.772), although no clear decision can be made about which model fits the data better

Finally, while much research has focused on the gut-liver axis, further investigation is needed to fully understand the systemic immunomodulatory roles of BAs and their impact on a broader range of cancers beyond primary GI/HB malignancies