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The mRNA expression of DKK3 is inversely correlated with its promoter methylation and may inhibit tumorigenesis and serve as a molecular diagnostic target (Zhao et al., 2020)

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Moreover, hierarchical clustering of the RNA-seq data revealed that samples grouped primarily according to their TOX condition, indicating a high degree of similarity in their global gene expression profiles and suggesting that the physiological condition is a major determinant of transcriptomic variation in our dataset (Figures 9C, 10B)