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Oct 24: Servier on Tuesday won its fifth FDA approval for Tibsovo (ivosidenib tablets)which also happens to be the first and only targeted therapy for patients with relapsed or refractory (R/R) myelodysplastic syndromes (MDS) with a susceptible IDH1 mutation

The single Phase 1 trial remains unpublished

2019;14:e0214714

A clinician may consider discussing MOTS-c when the bigger pattern includes: Early insulin resistance markers or metabolic syndrome risk factors Weight gain paired with fatigue, despite stable routines Training that creates soreness, but not adaptation Sleep disruption that keeps the nervous system in high alert This is where a plan should be built with guardrails