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Description

In contrast, it may take up to 48 hours for target cells to respond to certain reproductive hormones

Pregnant or nursing women should avoid DSIP due to the lack of safety data in these populations

Conversely, decreased GH/IGF-1 signaling has also been shown to extend longevity in a wide variety of species such as worms, fruit flies, mice, and yeast (468), thus raising the question of whether decreased activity of the GH/IGF-1 axis might be beneficial for human longevity