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Potential side effects can include, but are not limited to, the following: Acute kidney injury (typically due to nausea and vomiting) Diabetic retinopathy (damage to the retina, the light-sensitive layer of tissue at the back of the eyeball) Gallbladder dysfunction Abdominal pain and/or bloating, constipation, diarrhea, nausea and/or vomiting Decreased appetite, which can lead to weight loss Increased heart rate Medullary thyroid carcinoma (cancer of the thyroid gland)

It is thought that the peptide may directly affect metabolism in such a way so as to reduce complications separate from its effects on obesity

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Fat metabolism: GH enhances lipolysis (fat breakdown), potentially complementing semaglutide's weight loss effects while shifting the ratio toward fat loss rather than muscle loss