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Critical smooth muscle cell chemoattractants and growth factors include PDGF isoforms, (137) matrix metalloproteinases, (138) fibroblast growth factors, (139) and heparin-binding epidermal growth factor (Figure 3) (140)

Therefore, beta-blockers can attenuate these sympathetic effects and decrease sinus rate, decrease conduction velocity (which can block reentry mechanisms), and inhibit aberrant pacemaker activity

[14] As the pyridoxine molecule can be gradually degraded by exposure to light, it is advisable to store the vials in their carton or in a light-resistant container to minimize light exposure