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In brief, it appears that Cu efflux from the atherosclerotic lesion walls during the pathogenesis of atherosclerosis leads to Cu deficiency in the injured vessel tissue and Cu elevation in the circulation

Among these systems, glutathione (GSH) peroxidase 4 (GPX4) plays a dominant role by converting LOOH into nontoxic lipid alcohols (LOH) using GSH as an electron donor 10

Les exprimentations animales et les premires tudes cliniques ont confirm que la chimiothrapie et la radiothrapie sont mieux tolres si les patients sont soutenus par le glutathion pendant une certaine priode de temps