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Given that the intestinal epithelial barrier function was found to be positively regulated by activation of the intestinal cannabinoid type 1 receptor (CB1R) 27 , we treated mice with ACEA (arachidonyl-2-chloroethylamide), a selective CB1R agonist 28 during the autoimmune noninflammatory pre-phase of CIA from day 17 to day 27 after immunization

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Similar content being viewed by others Introduction Protein splicing is a post-translational process by which an intervening polypeptide, called an intein, catalyzes its own excision from the flanking polypeptides, or exteins, as well as ligation of the exteins (Figure 1A)