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The deficiency of monoamines such as dopamine and serotonin, a well-known contributor to mood dysregulation, is a strong indicator of altered cellular function of the earliest stages of AD pathology (Nyarko et al., 2019

The full sequence of FOXO4-DRI is: H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-Gly-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-Gly-OH researcher6076 April 28, 2026, 11:25pm #7 100% agree that is just the FOXO4-DRI payload without the CPP tail

(1982) Science

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