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About 90% of patients in both groups were also taking riluzole (an approved ALS therapy sold as Rilutek, Tiglutik, or Exservan) during the study

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Upon oxidative stress or electrophilic challenge, Nrf2 dissociates from Keap1, accumulates, translocates to the nucleus, and binds ARE sequences, initiating transcription of protective genes including HO-1, NQO1, and GSTs, substantially amplifying the cells antioxidant capacity (Jayakumar et al