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Most patients with vitamin B 12 deficiency encountered in dental clinics have a history of gastrectomy due to gastric cancer

TMEM106B is known to form homodimers, which can be detected either by co-immunoprecipitation (co-IP) experiments [134, 135] or by SDS-PAGE under non-reducing conditions [136,137,138], although the functional importance of the dimers remains unknown

To further investigate the affected metabolic pathways, we performed enrichment analysis using the small molecule pathway database (SMPDB) (Fig