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The histological changes associated with the diseases described in the following may be recorded using the nomenclature described previously under inflammation and inflammatory cell infiltrates but they are also presented here as a separate category of disease diagnoses to help pathologists diagnose the infections, which can be confirmed by PCR, immunohistochemistry, and other diagnostic studies

China Biotechnol

VacA exerts multiple effects on epithelial cells resulting in the induction of vacuole formation in the gastric epithelial cellular membrane, cellular damage, an increase of intracellular permeability and the modulation of apoptosis rather than release of pro-inflammatory cytokines (see Fig