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GTPCH is encoded by GCH1 , which is positively regulated by a variety of inflammatory and oxidant mediators, including lipopolysaccharide (LPS), interferon gamma (IFN-), interleukin 1 beta (IL-1) [3], tumor necrosis factor alpha (TNF-) [4], hydrogen peroxide [5], and others (Figure 1)

The following search keywords were used in the search of materials for this study: acute pancreatitis, NLRP3 inflammasome, inflammasome, medicinal plants, TCM prescription/decoction/formula, herbal extract, TCM extract, bioactive compounds, active ingredients, polyphenols, flavonoids, alkaloids, terpenes, anthraquinones, shikonin, polysaccharide, biological activity, pharmacological activities, and other similar keywords in combination with words such as traditional Chinese medicine, Clinical trials, botanical description, toxicity, human health, and nutritional composition

Although autism spectrum disorder has not been proven to exist either as a set of meaningful subgroups, or as the expression of a unifying deficit or causal pattern, nonetheless, autism appears to have been unified as a real entity in public opinion

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