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External application alone is difficult to significantly increase the proportion of fatty acid oxidation

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In patients with advanced cancer, a combination of the leucine metabolite -hydroxy--methylbutyrate (at 3 g/day), plus L-glutamine (at 14 g/day) and L-arginine (at 3 g/day) increased lean body mass.[26] A comparison of dietary essential amino acids with high leucine levels vs a mixture of essential and nonessential amino acids reported a higher anabolic potential in patients treated with 14 g of essential amino acids, independent of nutritional status, systemic inflammatory response, or disease trajectory.[27] Omega-3 fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), which are found in fish oil, have been investigated in cancer patients with cachexia