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In adults, the peptide is actually heavily modified in the brain to make it shorter, indicating that analogues like IGF-1 DES may have better therapeutic potential than intact IGF-1

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Cell culture and characterization The human BBB co-culture model based on stem cell-derived endothelial cells (hEC) and brain pericytes (PC) were established and characterized by the group of Ceccelli et al

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Neurology 2020;95(19):e2622-e2634 Seung Wan Suh, Ji Won Han, Ji Hyun Han, Jong Bin Bae, Woori Moon, Hye Sung Kim, Dae Jong Oh, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hui Kim, Seung-Ho Ryu, Seok Woo Moon, Joon Hyuk Park, Seonjeong Byun, Jiyeong Seo, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study

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Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

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