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These findings support the possibility that, at least in some patients, an abnormal (mutated) cancer antigen may be the initial trigger for an autoimmune T cell activation in SSc and autoAb recognizing the mutated RNApol III, which then cross-react with the wild-type autoantigen

All cryo-EM data were collected on a Titan Krios 300 kV microscope (Thermo Fisher Scientific) equipped with a GIF-Quantum energy filter (Gatan) with the slit set to 20 eV and a Gatan K3 Summit direct electron detection camera (Gatan) at Case Western Reserve University

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Characterization of Myeloid Leukocytes and Soluble Mediators in Pancreatic Cancer: Importance of Myeloid-Derived Suppressor Cells