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29,30,31 In addition, ROS-activated inflammatory cells, now acting as activated inflammatory cells, also generate ROS to further aggravate oxidative stress in tissues

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The regulation of the synthesis of glutamate from -ketoglutarate is subject to regulatory control of the Citric Acid Cycle as well as mass action dependent on the concentrations of reactants involved due to the reversible nature of the transamination and glutamate dehydrogenase reactions