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This irritancy test approach may be extended to other similar compounds or minerals and can potentially predict the in vivo skin irritation response before conducting clinical testing on human subjects

Hasel et al

At the same time, oxidative stress, which is caused by mitochondrial damage, activation of NADPH oxidase, and other environmental or treatment-related insults, promotes tumourigenesis through a cascade of events including: oxidative DNA adducts (8-oxo-dG), lipid peroxidation (4-HNE), protein oxidation, redox-regulated oncogene activation and mutagenesis, inhibition of the DNA repair machinery, and a vicious cycle of genomic instability accompanied by inflammatory signalling (178180)

Cell 162 (5), 11271139 (2015)