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The next step in enzymatic lipid peroxidation involves the formation of the corresponding derivatives AA-CoA and Ada-CoA catalysed by ACSL4 ( Antioxidant System It is now known that ferroptosis can be regulated by multiple parallel antioxidant pathways, for example, Cysteine/GSH/GPX4 axis, FSP1/DHODH/CoQ10 axis, and GCH1/BH4/DHFR axis

Supplementation of HepG2 with OA/PA boosted PG-PUFA 2 , perhaps to maintain plasma membrane fluidity during overloading with these non-PUFA

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