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Introduction With the coming of the modern society, chronic sleep loss or sleep deprivation (CSD) has gradually become a prevalent and severe public health problem that affected millions of people worldwide (1, 2)

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These studies will be critical for understanding the research utility of this pathway and identifying optimal applications for future investigational development

It was discovered that tesofensines ability to reduce food intake was primarily mediated through the stimulation of alpha-1 adrenoceptors and dopamine D1 receptors