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Alpha-Synuclein is localized to mitochondria-associated ER membranes

Accordingly, our work indicates that addition of N-glycan on Ea-domain prevents the degradation of proIGF-1Ea by the proteasome, probably overcoming the folding limitation of unglycosylated proIGF-1Ea and its entry into the ER-associated degradation (ERAD) pathway 40,41

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