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Suicide risk is high due to poor quality of life, with one example of a patient completely bed-bound for years who felt isolated, struggled with severe exhaustion and pain, often unable to speak or have the cognitive energy to focus, consequently deciding to end her life [19]

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however, some studies show that hypoxia inhibits the viability and proliferation of AD-MSCs and NP-MSCs while promoting chondrogenic differentiation ( Other MSCs such as placenta-derived (PMSCs), annulus fibrosus-derived (AF-MSCs), and peripheral blood-derived (PB-MSCs) also show enhanced proliferation, migration, or stemness under hypoxia (Ni et al., 2014