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When human amylin alanine at position 5 was mutated to serine (human calcitonin has serine as the corresponding residue to human amylin alanine at position 5), the mutation increased the potency of human amylin by 14-fold for CTR activation and by 9.1-fold for amylin receptor 3 activation

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This process depends on chloride and bicarbonate secretion, nitric oxidedriven ciliary motility, and bronchodilation to maintain mucus fluidity and clearance

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