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2024;5:e239

Nature 546 , 676680 (2017)

In this regard, it can be noted that transcription of the gdhA gene initiates from two promoters, one weak, constitutively expressed, called gdhA P1, and another, more potent, called gdhA P2, transactivated by GdhR, a transcriptional regulator whose DNA binding is inhibited by -ketoglutarate (Pagliarulo et al., 2004)

I also find in cases like yours that doing a full genetic panel is helpful, because then you will not only have a better understanding of the cause, but also what to do to help your body feel better