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Early understanding of glutathione metabolism indicated abnormalities in neurodegenerative diseases and preliminary work on the redox environment of FRDA patients indicated heightened oxidative stress biomarkers including blood malondialdehyde and urine 8-hydroxy-2-deoxy-guanosine (8-OHdG) (Schulz et al., 2000)

Breaking Through the Therapeutic Ceiling: What Will It Take

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For instance, co-treatment with CBD and cisplatin promoted cell death in head and neck squamous cell carcinoma (HNSCC) in cellular assays and a xenograft animal model ( 19 and cisplatin showed strong synergistic effects with CIs in a range of 0.10.3 ( 19 and cisplatin did not significantly increase the iron and ROS levels in Caov-3 cells