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In pediatric patients treated for upper limb spasticity, upper respiratory tract infections were reported more frequently as an adverse reaction in patients treated with BOTOX (17% at 6 Units/kg and 10% at 3 Units/kg) compared to placebo (9%)

In early studies, the proximity of fluorescently labeled sites on biological macromolecules was analyzed by the ensemble FRET, which provided averaged information about the distances between labeled parts of proteins

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