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Critical Care Clinics

(2020) 76:e159240

Thirdly, MDSCs can express and secrete VEGF, IL-1/2/10, TGF-, PDL 1/2, inducible nitric oxide synthase (iNOS), indoleamine 2,3-dioxygenase (IDO), and arginase-1 (ARG-1), which could recruit immunosuppressive cells and induce tumor immune evasion (162, 163)