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GH axis stimulation in pre-clinical ageing models: Studies examining GHRH analogue + GHRP combinations in aged rodent models documented restoration of GH pulse amplitude and IGF-1 levels toward younger values with findings establishing that somatotroph GH secretory capacity is largely preserved in aged animals despite reduced hypothalamic GHRH drive, and that pharmacological dual-pathway somatotroph stimulation can overcome age-associated GH decline

Ann Clin Transl Neurol 6(8):14351444

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For CD patients, inducing and maintaining a state of deep remission is the treatment goal