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doi: 10.1097/apo.0000000000000510 90 ChalkeSDKalePP

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Unique roles of Schistosoma japonicum protein Sj16 to induce IFN- and IL-10 producing CD4+CD25+ regulatory T cells in vitro and in vivo

Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis (Bansal et al., 2025)