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Upregulated expression of Tumor necrosis factor alpha (TNF-) promotes the transcription, that is the formation of mRNA transcripts, of Nuclear factor kappa B (NF-B)

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Here, we systematically review the hepatoprotective activity and molecular mechanisms of the natural products that are found to counteract the hepatotoxicity caused by APAP, providing reference information for future preclinical and clinical trials of such natural products