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When combined, they create a more natural and sustained GH secretion pattern, mimicking the body's own pulsatile rhythm more closely than either peptide alone

In many cases, combining peptides yields the best of all worlds : Its common to use a Sermorelin + Ipamorelin or CJC-1295 + Ipamorelin combo to harness both GHRH and GHRP pathways

Accordingly, this system could be developed for various clinical applications, including the treatment of familial short stature, cancer cachexia, eating disorders, and sarcopenia (Kojima and Kangawa, 2005)

Additionally although signalling via growth factor receptors can be oncogenic the same receptors can also drive apoptosis within cancer cells ( IGF mutations do not occur frequently in cancer indicating that it is often not an initial driver of tumourigenesis (Simpson et al., 2017)