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In addition to energy production, vitamin B12 is essential for maintaining the health of the nervous system and red blood cell production

Intrinsic factor, a protein that shuttles B12 through the absorption process, becomes saturated after a meal containing an above-average amount of B12 and about 4 to 6 hours are required before it can efficiently absorb another dose (IOM, 1998)

How a B12 deficiency causes fatigue Your cells need B12 for proper function, and without the necessary amount, your red blood cell production decreases, which makes delivering oxygen to your cells more difficult

"Vitamin B12 deficiency A 21st century perspective"