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In a previous 2D, BC cell culture investigation, elevated concentrations of Vit-C (10 mM or 20 mM) induced cytotoxic effects in MCF-7 cells, whereas MDA-MB-231 cells remained unaffected [38]

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Meanwhile, according to the lung histology score of inflammation, GSTP remarkably reduced the inflammatory infiltrate increased in CLP mice, which might lead to the decrease of the higher level of HMGB1 found in the serum and mortality of mice (Figures 1AC)