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It seems that the cytosolic Trx system does not play an important protective function against singlet oxygen (Gutirrez-Escobedo et al., 2020)

When co-cultured with microbiota, they reveal critical insights into cross-kingdom metabolism: for instance, gut microbes have been shown to enzymatically degrade CNMs (e.g., GO, SWCNTs), fermenting them into butyrate, which then modulates epithelial stem cell proliferation and barrier integrity ( Firmicutes/Bacteroidetes ratio, with downstream effects on mucus secretion and mucosal immunity (Hao et al., 2022