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Also, G127X patients had aggregates in glial cell nuclei of spinal cords, some of which were stained with an antibody (Chi 131153 ab) raised against a peptide sequence absent in G127X-mutant SOD1 (Asn131 - Gln153) [46]

The equilibration that results leads to a collapse of the proton-motive force across the membrane and a colloid osmotic pressure that causes massive swelling of the mitochondria (McStay et al., 2002)

Selective protein arylation and acetaminophen-induced hepatotoxicity

This process takes place primarily in the mitochondrial cristae, and when electrons leak from the ETC, they react with oxygen to form superoxide anions, a key source of mitochondrial ROS (34)