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Arrestindependent signaling in GnRH control of hormone secretion from goldfish gonadotrophs and somatotrophs

Cysteinylglycine or -glutamylcysteine have been proposed as possible alternatives.In a trial of adolescents with poorly controlled type 1 diabetes, a dose of 30-45mg/kg/day NAC failed to correct several markers of glutathione status, suggesting either a higher dose or alternative therapies may be indicated in this population.A recent study of patients with poorly controlled type 2 diabetes found that dietary supplementation of the amino acids cysteine and glycine, markers of glutathione synthesis and plasma oxidative stress were both improved

There is a theoretical concern (and some limited clinical evidence) that high-dose antioxidants like ALA could reduce the efficacy of these treatments

& Talalay, P