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Availability: InStock
Rating: 4.854100000000001 (20 reviews)

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Description

JAMA 261 , 732734 (1989)

After 8+ weeks: Maximum benefits from the current cycle typically plateau

These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time