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SIRT1, SIRT3, and SIRT6 promote mitochondrial biogenesis by deacetylating PGC-1, jointly forming a precise defense network for cells against oxidative stress (99)

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Systems such as dual oxide antigen-captured nanosponges, self-cascade penetrating nanoflakes, and nanosponge-mediated dendritic cell modulation have demonstrated how structural optimization within complex immune microenvironments can achieve precise targeting and enhanced immunoregulatory activity [71,72,73,74]

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