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10.1016/j.nbd.2018.11.025 103 Edaravone (MCI-186) ALS 16 Study Group

U.ZwanzigerD.BhmeI.JavedM.NaseerH.HyderS

Substituting a helix-favouring alanine at that position is a potency modification of a kind long documented in the GRF structureactivity literature it raises GH-releasing potency in isolated pituitary cells, an assay that reflects receptor affinity rather than pharmacokinetics