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Vascular elements on hematoxylin and eosin stained slides as well as immunohistocemically positive elements were examined in a blinded fashion using hot-spot assessment and ISSA program (VAMSTEC, Zagreb, Croatia)

The clinical data supports this as a rational escalation strategy, though it requires access to investigational cagrilintide

Other reviews also support this idea

Therapeutic peptides in orthopaedics: Applications, pathways, and tissue mechanisms [Review of TB-500 as thymosin beta-4 fragment in preclinical models]