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10.1074/mcp.RA118.000690 [DOI] [PMC free article] [PubMed] [Google Scholar] 135.Wang D, Zhao L, Zheng H, Dong M, Pan L, Zhang X, et al

Two FDA-approved alpha-2 agonists for hypertension treatment are methyldopa and clonidine, and dosages are dependent on the name and route

These medications dont just increase serotonin levels in the brain they also trigger a chain reaction that boosts BDNF production

Based on this mechanism, targeting HDAC6 to reduce EGFR activity may become a potential therapeutic strategy for the treatment of PKD (Liu et al., 2012)