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This is because mass spectrometry-based proteomics workflows, the preferred method for studying PTMs on a proteome-wide scale, include the reduction and alkylation of disulfide bonds as one of the first steps in sample preparation, which results in the loss of any cysteine PTMs that were present 2

10.1038/s41585-018-0109-7 65 MilenkovicU.IlgM

Though it will not feel like a hospital IV, there are some minor risks of bruising or of an irritated vein when injecting into the bloodstream, as with any IV delivery