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The body responds to this constant rubbing by producing more melanin (the pigment that gives skin its color) as a protective measure

Plant J 37:104114 Kortheerakul C, Kageyama H, Waditee-Sirisattha R (2021) Molecular and functional insights into glutathione S-transferase genes associated with salt stress in Halothece sp

Overall, melatonin's ability to affect multiple pathways involved in the pathophysiology of FM makes it a promising adjunctive treatment for this chronic pain syndrome [66, 67]

Then tetrahydrofolate is catalyzed by serine hydroxy methyltransferase to produce 5,10-methylenetetrahydrofolate (5,10-MTHF)