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IGF-1R expression is a pre-requisite to EWSR1-FLI1 mediated transformation [87], required for ES cell survival [88], and attenuates the efficacy of cytotoxic chemotherapy [89]

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By analogy with findings in other cell types, MAMs may potentiate the activity of Ca 2+ -dependent enzymes in the TCA cycle by regulating Ca 2+ transfer between the endoplasmic reticulum and mitochondria, thereby potentially enhancing mitochondrial OXPHOS efficiency and ATP production.However, direct evidence supporting this mechanism in ovarian cells is currently lacking