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doi: 10.3389/fphar.2021.643283 Received 17 December 2020 Accepted 04 March 2021 Published 18 May 2021 Volume 12 - 2021 Edited by Ales Tichy, University of Defence, Czechia Reviewed by Harold Swartz, Dartmouth College, United States Abdallah El-Sayed Allam, Tanta University, Egypt Klara Kubelkova, University of Defence, Czechia Updates Copyright 2021 Hollingsworth, Cassatt, DiCarlo, Rios, Satyamitra, Winters and Taliaferro

Three-fold increases in the percentage of IL-17A(+) GDL T cells were observed in skin cell suspensions derived from IMQ-treated PD-1KO mice (versus WT controls), suggesting that the lack of PD-1 has a functional effect not only on alphabeta T cells, but also on GDL T cells, and that PD-1 may play a regulatory role in PsD

Blanco, A.R.A., Paez, A., Gerold, P., Dearsly, A.L., Margos, G., Schwarz, R.T., Barker, G., Rodriguez, M.C

They also highlight the vital role of circadian rhythms in the maintenance of intestinal barrier integrity and metabolic health, and suggest that targeting the circadian clock or intestinal barrier components, such as occludin, may help to mitigate alcohol-related hepatotoxicity