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Description

The synchronization of peripheral clocks is not only hierarchically and vertically controlled by the hypothalamic master clock through the peripheral nervous system, but it also horizontally achieved through both humoral and non-humoral pathways

10.1111/j.1439-037X.2008.00301.x 55 DumvilleJ

doi: 10.1111/jocd.12751

In tumor therapy, engineered magnetic microspheres induce TAMs polarization to the M1 phenotype through the TLR4/NF-B pathway, which reduces the expression of SLC7A11 in tumor cells and thus increases ferroptosis sensitivity (234)