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While it is uncertain whether these alterations also involve modified incretin responses, within the framework of obesity, MetS and the use of hydrochlorothiazide for treating hypertension associated with these conditions, these findings suggest an intriguing hypothesis: that overweight or overnutrition might amplify the metabolic effects of these diuretics by inhibiting NCC and/or other targets in -cells and in metabolically active tissues but independently of insulin secretion

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Dewanjee S, Chakraborty P, Bhattacharya H et al (2022) Altered glucose metabolism in Alzheimers disease: role of mitochondrial dysfunction and oxidative stress

Now I want to hear from you: Do you know if you are B12 deficient