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Increased risk of cognitive impairment in patients with diabetes is associated with metformin

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(2) Minimizing the toxicity of complex nanostructures to prevent or reduce the additional side effects of nanocarriers, such as cardiac, renal, and hepatic function damage, as well as damage to the nervous system caused by crossing the bloodbrain barrier

The reported adverse reactions following parenteral administration of vitamin B12 include: Generalized : Anaphylaxis and death Cardiovascular : Pulmonary edema and congestive cardiac/heart failure during early treatment