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The presence of 75 Se in the brain after the injection of labeled 75 Se-selenite to Se deficient rats was observed only after the appearance of 75 Se-Selenop in the blood plasma, differentiating the brain from other tissues ( 75 Se-labeled Selenop caused five-time higher accumulation of 75 Se in the Se-depleted rat brain 2 h later than that in Se-sufficient animals ( In recent years, our understanding of Se transport to the brain improved considerably

For fairly mundane reasons owing primarily to safety and convenience, chromic acid tends to be made in the reaction vessel as needed (through addition of acid to a source of chromium), rather than being dispensed from a bottle

Such a mechanistically informed and patient-tailored strategy may ultimately shift sepsis management from generalized supportive care toward targeted, disease-modifying therapy

doi: 10.1038/hortres.2017.35